Join John Malanca and he sits with EndoCanna Health Founder and CEO as they discuss YOUR DNA and what Cannabinoid is right for you.
Len created Endocanna Health to answer one simple question: How do we help everyday people find a CBD or cannabinoid product that’s right for their unique needs?
Endo·dna is a simple DNA test that maps your endocannabinoid system and then matches that summary with a specific cannabinoid ratio and terpene profile aligned with with your unique genotype. Endo·dna is precision cannabinoid medicine, backed by the science of genomics, to ensure an optimal experience for every customer.
We’re a team of passionate, dedicated, and committed professionals. Many of us have been involved with cannabis therapeutics for more than 10 years – as researchers, scientists, activists, and advocates.
You can find Len and his team at https://www.endocannahealth.com For 20% off his tests, you can use Promo Code UPG20
Visit us at: https://www.unitedpatientsgroup.com
Follow our Podcast: https://www.buzzsprout.com/1129859
Follow us on Twitter: https://www.twitter.com/upatientsgroup
Facebook: https://www.facebook.com/UnitedPatientsGroup/
Join John Malanca and he sits with EndoCanna Health Founder and CEO as they discuss YOUR DNA and what Cannabinoid is right for you.
Len created Endocanna Health to answer one simple question: How do we help everyday people find a CBD or cannabinoid product that’s right for their unique needs?
Endo·dna is a simple DNA test that maps your endocannabinoid system and then matches that summary with a specific cannabinoid ratio and terpene profile aligned with with your unique genotype. Endo·dna is precision cannabinoid medicine, backed by the science of genomics, to ensure an optimal experience for every customer.
We’re a team of passionate, dedicated, and committed professionals. Many of us have been involved with cannabis therapeutics for more than 10 years – as researchers, scientists, activists, and advocates.
You can find Len and his team at https://www.endocannahealth.com For 20% off his tests, you can use Promo Code UPG20
Visit us at: https://www.unitedpatientsgroup.com
Follow our Podcast: https://www.buzzsprout.com/1129859
Follow us on Twitter: https://www.twitter.com/upatientsgroup
Facebook: https://www.facebook.com/UnitedPatientsGroup/
John Malanca 0:02
Hey everybody, John Malanca here with United Patients Group - Be Informed Be Well and I'm with an old friend and colleague Len may from endo Khanna health lead, how are you doing? Good to see
Len May 0:13
you too, brother appreciate it man.
John Malanca 0:14
We I don't want to say we're pioneers or I don't want to say we're old. But we're getting to the point where we're considered pioneers in this industry.
Len May 0:22
Every one of these gray hairs is earned.
John Malanca 0:25
Well, I have when I don't show you that I used to see it like that. And if if I didn't have my hair slicked back, you would see the grays in there. But anyway, thanks for being on. Blessings to you, your family and everything else like that. Endo Cana healthy. I mean, you've been in this in this sector cannabis sector for quite some time. And you deal with DNA, the body and the endocannabinoid system as well as different cannabis varieties when treating different ailments. And so you've you've there's a kind of science behind it, but also medical behind it. And so before we get into that, I'm going to just start throwing questions at you. What's the end? What's your version of the endocannabinoids? What's your definition? I should say the Endocannabinoid?
Len May 1:11
Well, I mean, the way that I like to explain it, the way that I understand it, it's a primary regulating system and modulates all the other systems within our bodies. And the way that it does that it it gets signals from the other systems and sort of like, think of it salmon swimming upstream, it goes up the central nervous system to the brain, than the brain makes a decision what neuro chemicals to release in order to help maintain balance in the other systems, or what's called homeostasis. And the two endogenous neuro chemicals that the endocannabinoid system uses are anandamide, which is, the word anon means that bliss in Sanskrit and also to AG. And, just in general, the way the way that it works is when when we have a situation, maybe stress, or, you know, somebody cuts us off as walking down the street, we have all these neuro chemicals are pumped into their bloodstream, we have some dopamine, some adrenaline and norepinephrine, some cortisol, then once we realize there's no lion chasing us in the jungle, those neuro chemicals start being taken back up re uptake process, and then our brain will release those neuro chemicals that I mentioned, as well. And that's to get us back to the balance and homeostasis. The challenge is, we are all individuals. So 99.9% of us are identical is a point 1% That really makes a difference. And at that point, 1%, there are certain, certain enzymes that we have as individuals that may secrete less of our endogenous endocannabinoids than you know, our neighbor next door to us. So when that happens, we are lucky that we found this plant in nature that actually has receptors within our body that can create some of these kind of bridge some of those deficiencies. So, as I was given that example of you know, stress, now our brain is going to release an animate into AG. So the two ag will go in and help to reduce some of the inflammation from an overactive immune response. And the anandamide will help to be able to get us back to that that feeling of balance from stress. But if we have certain genotypes, there's a gene called as an example, I know you didn't get into it yet, but I just since we're talking about the endocannabinoid system, just wanted to see show people that there's a difference and how individual endocannabinoid systems work. There is a gene or single nucleotide polymorphism, called Five fatty acid amide hydrolysis. So that specific gene produces an enzyme that breaks down or metabolizes anandamide. So person that has a certain genotype, which is called homozygous and I'll get into that later on, they actually metabolize and break down more anatomy. So they produce less anatomy than the average population. So in that situation, that cortisol level in the individual stays longer in their bloodstream. And if that's the case, they can have an overactive immune response, which we will feel as pain, inflammation. So people come to you to us and it's a pain, okay, pain, pain, to me is a symptom. What else is going on there? Maybe there's an imbalance in your endocannabinoids system. What can we do to make sure that we bridge that gap and what you're naturally not producing? So by consuming, you know, phyto cannabinoids in the plant, it'll bind to that CB one receptor THC or delta nine THC and a release more an antibody can bridge so that's really the way that the Endocannabinoid and modulates all the other systems within the body like I mentioned, and That's really how it works gets those signals. And it's always always working. But we have to make sure that we understand that everybody has their own individual endocannabinoid system.
John Malanca 5:10
Well put I love your description of the salmon swimming upstream as well. You know, we're, I always say cannabis is not a one size fits all what works for me may not work for you and vice versa. Before we get into endocannabinoid endo Canna health you hear DNA everywhere now, you know, ancestry.com 23 and me. So what what is DNA?
Len May 5:39
Yeah, DNA is basically our material of life. So when we're born, we get DNA from both our parents 50% For our mother 50%, from our father. And the way I like to describe DNA, think of it as a big thing of on and off switches. And so when we get these, some of the on switches are turned on for us. So we're born like, like our skin color, our eye color, hair color, all these switches are turned on, the rest of them are encoded messages, they're encoded in our, you know, in ourselves personally, and our lifestyle, what we do will dictate whether we want to turn those switches on and off. So the way our lifestyle what our nutrition is, or mine, our mindset, you know, stress levels, exposure to heavy metals, all these things can dictate the expression, which is called epigenetic. And the way that that works is you have your DNA, then you have which is your encoding, then you have messenger RNA that goes from that DNA that gets the message and send it to another place with messages to create certain proteins. And these are the proteins or building blocks that we need in order to turn those epigenetic expressions on or off. Now, I feel everybody should know what their genetic predispositions are, regardless of cannabis or the endocannabinoid system just in general, because if you know these predispositions about yourself, you can take specific action to turn those on and off. And the way DNA communicates to us is, like computers have a binary code once and zeros. And then we have a user interface on top of that. And DNA communicates in a four letter code, a C, a T, and a and a G, which are called nucleotides. The combination of those two letters are your genotype, and that genotype is your point 1%. What makes you unique? And what when you look at a DNA report, they talk about a variant. So a variant is basically What difference do you have in you from the average population. So somebody may be is more predisposed to x, somebody who's maybe less predisposed to x. So it can be examples like, if you have a predisposition to alcohol dependence, well, you may know that about yourself because you know, grandpa and, and everybody else down the line there, but there is a gene for that. Or maybe even more important, if somebody has a predisposition to opioid dependence. Now you go to your health care professional, your pain management specialist, and somebody and they give you an opioid, well, one of four people, one in four people may have a predisposition to opioid dependence. And if you're one of them, that can trigger that on switch, and now you're gonna have a hard time. So understanding how to navigate through those and avoid those potholes in the road. That's where you're empowered with information, some things you do want to turn on. And some things you want to keep turn off. If somebody has a predisposition to, you know, cancer we've used, we use this brockagh kind of gene for for 50 years looking at, you know, breast cancer, etc. So if you know this about yourself, there's things that you can do, your DNA is not locked in, it's not your sentence, you can control the epigenetic expression of that, when you turn those switches on and off
John Malanca 9:15
with with this I'll use credit as an example. You didn't you, you, you, you knew Corinne, and you know, cancer was in her family, her mother had breast cancer. Her father had cancer a couple of times. So, uh, you know, that's one thing we always discussed, you know, is she and her siblings? Are they sitting sitting ducks? You know, we stayed on top of this health, you know, we did our blood tests on a regular basis just to see, you know, and I'm a big fan of blood tests, and I've shared this numerous times on a lot of my shows is, you know, going through a blood test with a naturopathic doctor and And D is acronym. And these will give you a blood test A through Z naturopaths will go a through Double Z, and they will see where you're high on while you're low on where you're tired while you're gaining weight cortisol level oxygen and in your in your blood. I mean, the first time I did it, they said, I can tell John that you're sitting down. Because what right when we when we stopped, we launched United pace group 2011. I did my first test. John, I see you're sitting down. Because the oxygen in your in your system. I can tell you're only using half capacity, your lungs, does your back hurt, does your hips hurt? And I'm like, I'll be down. It was because I was sitting down. So the first thing I did, I went and grabbed, you know, standup desk and got back into my workout routine. But we were just so engulfed with starting United patient group that I had to really change myself to get back and I tested myself a couple months later and everything was back. So that's that's why it's really important to stay on top of this. Endocrine of health, with let's talk about so thanks for endocannabinoid system as well as DNA. So what does endo endo CanadaHelps? Do? Not only with DNA but with patients?
Len May 11:07
Yeah. So the goal of our company, I'll just say we met with the FDA, they asked us what is the purpose of your test. And we said to help individuals avoid a possible adverse event with their cannabis use. So we're not here to find what you know cultivars is going to get you the most high and anything that it's not about that it's about grandma Mary, to make sure if she's going to consume cannabis. For, you know, the side effects of her chemo treatment, we want to make sure that she avoids those adverse events. So the way that it works is it's a DNA test. When we first started, we did research and we looked at every single gene or single nucleotide polymorphism that has a direct or indirect association with the endocannabinoids system. Once we found all the different snips, and we made, we need to make sure that they have a peer reviewed reference of a PubMed quality or equivalent to so that everything has to have a reference. Then we approach a company called Illumina who makes genetic equipment, genetic sequencing and genotyping equipment, and we ask them to make a chip for us, and I'll explain why a chip and how that works. But so they said they have this chip, it's called it does a global screening. But when we looked at the Global screening chip, it was missing a whole bunch of specific endocannabinoid markers. So what we did was we gave them and we created a custom chip. So we genotype and sequence 675,000 different genes. Right now. They're directly or indirectly associated with the endocannabinoid system.
John Malanca 12:46
Can you repeat that number?
Len May 12:48
675,000. In all humans have
John Malanca 12:51
that many? Well, are you good?
Len May 12:54
Good question. We're testing. We're testing 675,000. Now, we just finished our assay to validate a whole genome sequencing. So we're going from 675,000 to 64 million. So it's not even the endocannabinoid system, we're going to be looking at nutrient deficiencies, vitamin deficiencies, anything and everything that we can do and individually skin, you know, what kind of skin conditions are you predisposed to what topicals may be more aligned with you or not. So all these things and then disease markers as well. So we have, you know, healthcare professionals that work with us through our clinics through telemedicine and in person, and they can talk about specific diseases which the test currently, Director consumer does not we talk about symptomatic conditions. So an example would be Parkinson's, let's say the test is not going to talk about Parkinson's as a disease. But we can talk about tremors that are associated with the disease of Parkinson's. So the way that we get information, I'll describe what you get as well, we get a twofold number one, there is a buccal swab. So you get a test kit, it's endo DNA, you get the kit, we're HIPAA and GDPR compliant, you would swab the inside of the cheek, you were registered on our portal, my DNA live, and you would put it back in a box and ship it to our lab. Once you register, there'll be a timeline will say the sample has reached lab. It has been extracted genotype and your results are ready. So that's the one way to get your information. The second way to get your information is if you've already done a 23 mi or an ancestry. What you can do is take the raw data that you already have uploaded to our site, and we'll give you results in about 30 seconds or less. Wow. And when I talk about results
John Malanca 14:44
for our listeners, this is audio and in video and for audio. I'm on lens website right now endo dna.com en do D a.com And so what Len is talking about right now I'm kind of scrolling through the website as to what's going on. So I didn't want to cut you off there either.
Len May 15:10
No, that's exactly it. So when you when you receive, I mean, you shown the right things on the screen, when you receive the report. It basically looks at all the different symptomatic conditions associated with cannabis use, and, and where you DNA can make a difference. So things like anxiety and stress, mood, sleep, pain and nausea. Side effects of THC, maybe some people are predisposed to some side effects. Some of them are common to just about everybody working memory impairment. Yes, right here, what I'm consuming cannabis, I'm looking for my glasses for a half an hour there on top of my head, you know, and, and also, you know, psychomotor control, so you shouldn't operate, you know, heavy machinery. However, I tend to drive better under the influence of cannabis than the the nod more careful, but you're not supposed to. So we're just between us, John, we're not we're not letting anybody else know. But but some things can be much more serious. Like there's a predisposition to psychosomatic effects, which is psychosis like effects. Now, I've seen this happen maybe a handful of time in the last 10 years or so. And it's a perfect storm that happens. And the perfect storm is somebody has a predisposition to stress reactivity, PTSD, maybe slow rate of fear extinction. And when they consume an edible, which is high amount of THC, when it goes to their liver, there may be a poor metabolizer, which is something else that we look at, we look at how you metabolize dosing based on metabolic function. So there are poor metabolizer of THC, the liver is going to convert THC to love an oxy hydroxide, Delta nine is going to go back into your bloodstream, bind to receptors again, and be five to 50 times more powerful, but if you're a poor metabolizer, so number one, it's slower onset. Number two, it can last a lot longer. And if you have these predisposition to stress reactivity, etc. Now you're having a stressful that. And if you have a predisposition to psychosomatic which is psychosis like effects, it can trigger that sick psychotic episode, which is this associative experience. And I've had some people be, you know, hospitalized for that. So the idea is, if you don't know, it's trial and error, but at the very least, you want to make sure that you're you're looking at something. And the third part of that is drug interaction. So there's different prescription medications. So if I'm looking at the end of DNA test, there's three specific things that you will get from it. Number one, what aligns better with you what is the cannabinoid and terpene profile that you should be consuming for based on your genetic profile, and based on symptomatic conditions. Number two, we're looking at drug to drug interaction supplement to drug interactions. So all these different things. One can be an inhibitor, one can be an inducer, so don't take them the same time. And the third thing is dosing how much you should dose we always were taught first a low and slow and we'll still continue to say low and slow. But we were taught about, you know, milligram per kilogram, well, you know, I, my business partner and I are physically different. He's a bigger man than me and weighs more and is taller. If he and I both consumed exactly the same amount of THC, he will have a much more intense experience than me because I am a normal metabolizer and he's a poor metabolizer. So it does have to do with that. And then from all those things now that you know your ideal cannabinoid and terpene profile, now you can find products that are more aligned with you based and see a vase of different products and geofencing them.
John Malanca 18:56
So question for you. So you like I'm six 195 pounds and I'm very sensitive to salt, butter, alcohol, cannabis, I mean, I'm the type of guy that can have a glass of wine and be perfectly fine where I have friends that you know, drink three bottles of wine and they're perfectly fine. And the same thing with cannabis. I have success, you know, with a two milligram five milligram i Here's others taking 2550 100 I'm thinking boy, oh, boy. So with example, you just shared with me with your business partner there. Yeah. Can you see with his metabolism, metabolism being different than yours? Can you see if he predisposed of an ailment before it happens? Is this part of what what your test can show? Absolutely. Yeah, that's exactly what that really, that really can change a lot. I mean, not in all cases. I mean, currently, like I said, stayed on top of our health. When we asked her accurate, please. You know something that makes it come on guys, you guys are star patient or star pupils you do everything correctly you're supposed to do. And all the blood tests came back zero cancer. And it wasn't till three or four months later when we did an ultrasound is what actually showed and they said, Oh, these you know, I mean it's so having something like this for patients, family members, etc doctors even to share with their with their patients is really hate the term game changer. And I'll use it game a game changer because it can it can save a lot of people a lot of trouble. If it's the type of type of cannabis they're taking. Cannabis is not a one size fits all. And I'm glad you talked about the drug to drug interactions, I was talking about age, weight, as you're mentioning with your colleague, sensitivities the stage or the ailment, God forbid hope is not cancer. other modalities that the patient may be taking, but also drug to drug interactions. And so those are all things. And so that's part of your test. It shows cannabis, and I'll use a sleeping pill or aspirin or
Len May 21:10
a while. I'll give you an example. I'll give you so so we have over 200 different prescription medications. And now we're adding supplements as well. So when I had COVID, I was taking 14 different supplements at a time like how do I know how these interact? And can I take my CBD with that? And what about my other cannabinoids? So we started digging a little bit deeper. So right so I'll give you an example like blood thinner medication that has a specific interaction with things like warfarin. It can be an inducer, so you have to be really, really careful or SSRIs we get people to that contact us all the time. Hey, you know, I want to get off of my antidepressant and I'm taking cannabis. Okay, well, speak to your healthcare professional, or speak to one of our healthcare professionals. Well, we always tell do not consume your prescription medication together with your file cabinet, stagger your consumption. How long you stagger for depends on how you metabolize if you're an ultra rapid metabolizer, an ultra rapid metabolizer of of CBD. So there's three specific enzyme genes, just just for the audience to understand what that means. There are a series of genes called cytochrome P 450. So CYP 450 have create every enzyme that helps metabolize different things. There's one for lactose, there's one for gluten, CYP to see nine is one for THC. One nine is CBD, three, a four is CBD and THC together. So when you're consuming an isolated molecule of THC, there's a one enzyme that's breaking that down. But if you're combining CBD and THC together, as we refer to full spectrum, it's a whole different enzyme. So that's why people have different experiences when they consume one molecule versus you know, a whole plant.
John Malanca 22:55
Yeah. You talk about cannabis, as I was talking about Canada's in medicine, but you talk about cannabis as medicine. Now, when you're pairing that with, say, John Smith, or you know, and you're saying, let me be your DNA, are you pairing it? With a strain or formula? I'm you may correct me if I'm wrong, I'm not a big fan of strange because you and I get a seed from Hawaii, Maui. Wowie. I grew up in Northern California, I grew up Southern California, our colleague Rosa in Colorado, and someone else grows it in New York, same seed, or even same clone from the mother. They all come back different. And so when you're doing these tests, they say, okay, Mary, you're having issues this go try a Blue Dream strain strain, or how do you how do you make these recommendations?
Len May 23:51
And that's it. It's a great, great question. I'm not a fan of strains. Dr. Ethan Russo told me multiple times. What does a strain refer so virus? Why do we call this amazing plant a strain when it's not called the bar or a chemical right, a chemo bar, but the way that the test comes back, it comes back with a ratio of cannabinoids, let's say, you know, John Smith, you're you're better off with a balanced THC to CBD ratio, because you have some predispositions you need an agonist and antagonist of CB one and then they'll come back with primary secondary terpene profiles so maybe Linnell and beta reoffend to help take the edge off and beta three alpha will be something to help with the information. Now, what we do is we run an algorithm to show
John Malanca 24:40
you also testing so wetland which is talking about little blue. Those are types of terpenes terpenes everyone's very familiar with terpenes maybe not hearing the name but you know it by scent. Stop and smell the roses, the rose that the scent that puts off as a terpene to me roses, bring me back to my grand My mother, she grew the most beautiful roses in San Francisco. If you were like, how the heck did you do that? Also little blue, which is lavender for calming, you know, another scent that reminds me of my grandmother. And so they all play a role and so on your test your DNA test you they also, do you guys also pinpoint certain terpenes that are beneficial for each patient.
Len May 25:22
Yeah, absolutely, we look at a symptomatic condition, we give you a cannabinoid ratio, and a primary and secondary terpene profile, then what we do is, my background is plant genomic. So I used to do genetic sequencing of plants. So that's why I know you mentioned blue dream, I would get five different blue dreams, genetically, you know, sequence those and see, alright, two of them are identical genetically, two of them are crosses a blue dream, so they have some blue dream in them. And the fifth one's not even close to Blue Dream. And we still keep calling them blue dream. That's why these names are irrelevant. So what we do is we get brands or companies to provide us a third party, CMA certificate of analysis, which is a test result of their product. We run that through an algorithm, and it will show you what the percentage of match of that product is based on your genetic profile. So for John Smith, it could be flour too. But tinctures are probably the best way to be able to deliver some of that therapeutic medicine, because you can get really precise with the ratios. It's very, as you mentioned, it's difficult because genetic drift in flour, but the very least flour is your thing, then at the very least you can see, okay, let me find flour that has dominant linalyl and bakery offer, what are the different cultivars or chemical varieties associated with that, and then we show you the percentage of match for those specific products, maybe this is a 70% match, we geofence where you can find that product was what's the dispensary closest to you. And we have a feedback loop mechanism. So the feedback loop on efficacy works two ways. Number one, we have patient reported outcome. So patients will come back once a month speak to our care counsel, let us know. But more importantly, which creates a little bit of friction, because every single time somebody wants to report something, we always found somebody's you know, feeling better. They're not incentivized to report. But we also provide we have a biometric device integration with biometric devices. So we have our own device called the endo link device. And we also have we integrate with Fitbit and or et cetera. And we can provide you frictionless feedback, we can measure the things that we talked about, like blood, oxygen level, heart rate, variability, heart, Ellis disease, all these different things. And we can measure the formulation that you got, or what suggested for you, what's the efficacy of that, and we can modify that on a monthly basis, depending on how it's working for you. In addition, that data goes into the cloud, we use machine learning to make better predictive inferences. And we can make better predictive suggestions for more individuals that are archetypical. So somebody like John Smith, all right, that worked for John with his DNA, maybe there's 10 other people that are similar, similar height, weight, all these other things genotype and they've taken this formulation, and it worked for them. So this is how the ecosystem revolves.
John Malanca 28:14
Wow. You know, you talk about precise medicine. Can you talk about go further into that? And so talking about the different ratios, as well as the terpene, specifically designed that's coming off these tests? And so can you can you go more into the precision medicine, and then also the biometrics as well?
Len May 28:34
Yeah, well, precision. So precision medicine, the way we look at precision medicine, when we you deal with our health care professionals, you mentioned bloodwork, so blood work is a moment in time. So what we want to do is we want to take blood work. And we want to add to that we want to look at your genetic predisposition, we were looking at your biometric feedback, we want to look at, maybe you have disease predispositions, and the protocol that is suggested for you, based on all these different labs is specific to you. So like if you have some sort of nutrient deficiencies, let's say you're low on iron, or you're low on calcium, or you have some vitamin deficiency, vitamin D, vitamin C, the we can suggest supplementation of that. And it can be delivered in an intravenous Li, for instance, so you have your own personalized IV treatment protocol for you based on what you're lacking right now. Also, based on maybe hormone levels as well. So we have our clinical or hormone levels, some people as as men age, and I'll speak for me, once you get past 50. Well, you know, you have to look at your hormone levels, what's going on? Is there anything that I need to supplement for so you have bioidentical personalized hormone level adjustments as well, and then other adjunct products that you can look at so the precision medicine is specific to a disease predisposition or predisposition to Other things that you may be symptomatic of, and has a completely precise protocol that is being measured on an ongoing basis with that patient reported outcome, and biometric feedback. And when I'm talking about biometric feedback, I'm talking about, like, what the device I'm speaking about what people know, like Fitbit and everything else. So yes, it measures your steps. But also, it can measure your blood oxygen level, it can measure, it can measure heart rate variability. But more importantly, we have these isolated labs set up. So sleep, for instance. So we have a lot of people coming to us with sleep with pain, I'm sorry, with pain, or saying, oh, you know, I am having some pain I can, you know, but when we communicate to them, we ask them, how is your sleep? Well, yeah, you know, it's problematic. Well, what do you mean by that? Well, I wake up a few times a night, or, you know, I have a hard time falling asleep. So sleep quality is really important. So what we will do is measure your alpha, your theta, what are the sleep quality that you're getting, and we'll plot that over time. And see the protocol that you're consuming is actually helping you with sleep recovery. And if that's the case, then it may be your daytime protocol, your anxiety, your stress, your mood may be affected there, you'll get off this hamster wheel. And the pain level can be caused. And I'm not saying it is specifically, but it may be caused from that cortisol release. So if you're stressed during the day, you have all this cortisol, you have an overactive immune response, oh, you know, my neck hurts, my back hurts, my knees hurt. Well, are you dealing with your stress levels? Are you sleeping, so it's a completely personalized approach to you know, medicine?
John Malanca 31:50
You know, everything you're talking about? It's, it's, I have, we have a lot of patients that will call they say I want to, I have an issue with sleep pain, depression, anxiety, etc, etc, etc. And a lot of times I say, for the women they call, I said not to get personal, but may ask how old you are. And I said, I would go get a blood test to see where your hormones are. They could be off and I could it's a domino effect of get that take care of the sleep. And guess what? You sleep the night you wake up? In many cases, not all maybe pain free. They're not in there. You know, they weren't tossing and turning all night in their bodies not all wrenched out. Their anxiety has dissipated. They're you know, and it's again, it's a dominant let's treat this and a lot of doctors we've had on the show, Dr. Behrman. Bless Dr. Frankel. You know, who's passed away last year. You know, we talked about Bonnie Goldstein, Dustin, talked about this, treat this first and then we'll the domino effect will go on one thing that you haven't mentioned and but you've tiptoed around not tiptoed, but you've thrown a little pieces at it. I'm a big fan of journaling. I tell tell families and patients even doctor have them journal. At this time, my pain level from one to 10 is an eight. Okay, I took I ingested some medicine and however, well, how do I feel now? But also write down? Did I exercise that day? Did I sleep well that night, that the night before? What food have I taken that I take my medicine before or after my food and so you can just kind of see where you are and go, Ah, okay, I'm seeing that I'm having a better result. Doing it in the morning, before meal after meal after a good night's sleep, et cetera. You've you've come a long way, man, I mean, you hearing all the things, because I do all this stuff. But I piecemeal it out from our doctors or this, you know, I'm acupuncture this, I get our blood test, you know, and but I think I'd love it that and I and I'm a big fan of IV treatments, from, you know, knock on wood, you know, we would never get flu shots. That was our flu shot, we'd get IVs. And they do everything from vitamin C to kidney and liver cleanse, immunity boost, et cetera, et cetera, et cetera. And so, you know, that's something that I that I that I have recommended and spoke about quite a bit over the years. We've done everything, patients that catching it before any ailment happens. What happens when you what can you recommend with a patient that has been diagnosed with something because when you get diagnosed, I'll say use credit example. To hear those words. You have cancer, you your life just comes to a halt. And you will try anything and everything And you know, if it says I was talking about if there's eat a blue pen, give me a whole box of them, you know, so you're trying everything. And it's I don't want to say it's a panic education form, but you're kind of going through something like that. Is this something that can be beneficial as someone that has been diagnosed with something as severe as cancer, that they can get a DNA test, see where they are, and hopefully try to find the ratio that works best for you. You know, Cohen's father had stage four lung cancer metastatic brain, his, for him, he had success with four parts THC, one part CBD, where others have had a one to one ratio with success. You know, we did everything with Corinne, you know, and she had pancreatic cancer, which some of our audience audience members know, and knew her and our new of new members, or followers. You know, that was my wife, Corinne who had, you know, didn't drink and smoke did everything you're supposed to do but was diagnosed with pancreatic cancer. And she lost her battle after four months. I can't tell you, Len, how many pancreatic cancer patients families that I speak to, that their loved one was diagnosed in 48 hours later, so they pass and so which is very common. So maybe all the things we did, from IV treatments, to different cannabinoids, you know, and we, I stayed, I had, I journaled everything when we did what she ate, the pain level and in the formulations that we put in there. And so with something like this, could this help a patient that has already been diagnosed is what I was.
Len May 36:47
Yeah, and I and I mean, what what you said about Cohen's right on? Yeah. And the people, people, it's really an individual thing. Do you want to fight? So unfortunately, a lot of people come to us or look at cannabis as a last resort. totally unfamiliar. And it shouldn't be. It can be an entry level work
John Malanca 37:12
combination. I tell people if you're gonna go that route, I'm not telling you to stop. You can incorporate cannabis, it's not going to zero the chemo radiation that you're doing risky beneficial for sleep, mood, appetite, pain relief? No, there's as well as healing. Yeah, there
Len May 37:27
are studies that you can find on PubMed that show the chemo with phytocannabinoid treatment is more efficacious than than each one of them alone. So yeah, absolutely. To answer your question, yes. So we're not a diagnostic test. If you're already diagnosed, you can speak to our doctors and find out what the protocol is. And if cannabis is something that you want to consume, that's part of your protocol, then absolutely, you should know exactly what type of cannabis work for you. And for different kinds of things of some of them can be the anxiety, the stress and anxiety you have to deal with, we're getting that diagnosis, let's see what we can do to find something calming, you don't want to consume something that's actually exacerbate that stress level, you want some that's calming. And once you find those things, and started dressing, those things, help your body to heal. We're not making any claims that you know, cannabis has been able to shrink tumors, et cetera. But it has been there are studies associated with that. So our goal is to be able to address those symptomatic conditions, while hopefully we can actually help the patient, you know, move on to a successful treatment, also, but it is truly a personal experience. And we're doing it we just are in a in the beginning of a pancreatic cancer study now under an IRB. So with a doctor group out on the East Coast, and it will be we'll be speaking and publishing on that, as well. We're in a phase two clinical trial with Harvard Medical, on the association of anxiety, and how cannabis can address a desire to stress. We just completed a study at CU Boulder on the correlation between stress and pain, and how cannabis can support with that also. So there's so many different factors. But once again, it is a personalized experience. It's not a panacea. It's like oh, I have something I'm going to just, you know, consume some cannabis and it's all goes away. It's all the things that you just talked about, John, it's being able to know yourself, take good care of yourself, put good things in your body, put good things in your mind, control your stress levels, reduce your exposure to mercury, heavy metals, all these different things and monitor yourself. The more you know about yourself, the more empowered you are to make those smart decisions in your own personalized health and wellness.
John Malanca 39:48
That I know we're both aging ourselves here but I turned I turned 55 This this last summer here. And you know I'm a big fan of supplements and I've taken supplements for years. And you know, I was turned on to by this my aunt who is a chiropractor in back in the 80s. You know, she's starting I was in high school, what did I know? And my first job in high school is was was Baskin Robbins. So I played that I was an athlete, but I was a, I remember, I was a chubby little kid and ate all 31 flavors every night, I worked. And I remember I went down and stay with my knuckle down in Southern California. And she picked me up at the airport, she looked at me, she says, Man, you want to be a fat little chubby kid restaurant like no. So she put me on that. And I'm still I'm still Rosalyn is her name. But I thank her because she she got me on that lifestyle change. When I was 16, I'm 55. Now, yeah, and I still, you know, ride or run every day, rain or shine. And as part of my routine, and I'm very fortunate, but I take supplements, you know, you know, I think it's really important to keep the inflammation down, keep the DIS ease, as you mentioned, you know, out of the body. And so, you know, something like this? You know, I'm going to, I'm going to try it. Yeah, do a test. So like. So there's two different things, I could one submit my ancestry.com or 23andme DNA test to you. Or if you don't have that, I can take a test directly from your company that will show my DNA and then with that, it can incorporate what type of cannabinoids work best for me, as well as supplements, as well as terpenes. Can you talk about that before we sign off?
Len May 41:45
Yeah, absolutely. That's exactly what you again. So you go into endo dna.com, you can order your full end of DNA test, which retails at for $199. And are given your audience a special discount. So you can communicate some of the codes up g 20. And that's the code that you can give to your audience. And it's across the board over any product that enter DNA. And I'm assuming that 20 to 20% off. Yes, 20% off any Yeah, so any products. And then the second way is if somebody's taking the 23andme ancestry, My Family Tree DNA, you can download your own data file, upload it to us, it's 4995 retail, and you'll get your results instantaneously, within 30 seconds or less. We'll go through a precise wellness plan, it'll have a health profile, which will give us a baseline and we can measure against that health profile. It'll give you your report on all the different symptomatic conditions, your process wellness plan on sleep, pain, anxiety, mood, cognitive function, etc. all the way to a cannabinoid and terpene ratio. And then in the marketplace, it'll show you products that more aligned with you. And then you can, if you choose to speak to our care counselor, or one of our physicians, we can talk about all the other things that we discuss supplementation, precise supplementation, hormones, all those other things and biometric feedback. The most important thing is make sure that you're on top of your health on an ongoing basis. One last example really, really quick. So i Blood i hate blood tests. I am all tattooed. So needles don't bother me. But it's that needle going into my vein extract, I can't stand it, it stresses me out more than anything. So I went and I got my full physical efforts or any 50, whatever. And the I got my results back and I'm speaking to and I go to an integrative functional doctor, and everything was perfect. You said your blood glucose levels a little bit higher. Like she goes, it might be due to stress. But if you're really concerned about where a glucose monitor and see if there's any changes, and that's why I want to bring this example because when I worked a glucose monitor for two weeks, everything was cool. I mean, one time at a Starbucks drink that I think had more sugar spike, my glucose level, but because when I did my blood work, it was a moment in time that cortisol level of stress was released. It actually accelerated more glucose, glucose blood glucose, so it showed it up on a test but if after I looked at it for next several weeks, and we looked at it again, it was fine in normal. So these things you have to be on top of it on an ongoing why? Because you're aware of it. Yeah, because I was super stressed. If you want to hear a funny last story, so I'm getting my bloodwork done. I told the doctor I don't do really well with bloodwork, I gotta lay me down. I start seeing stars. I've never actually physically passed out but I was close. So come in. In the morning they said don't eat or drink the right that's what I heard always in my life. If so I come in, I sit down this kind of lounge chair, and she's like, are you ready? Did you have anything to eat? No. Do you have anything drink? He said, No, because you're supposed to drink water. So what do you mean? Nobody ever told me? She goes, we'll have some water, because then now your blood. So she gave me like a little tiny bottle of drag that down. As she starts, were talking, she starts going fine, doesn't hurt. And we're talking and all of a sudden, I can't hear what she's saying to me anymore. And I hear in the background, hey, and she's calling somebody else to come help. And they run over. And then I kind of come true at it. And I'm like, what's going on? She goes, Oh, I think you were out of it a little bit. I'm like, Oh, let us give you some juice. Give me some juice. I'm drinking some juice. I'm like, Okay, I'm feeling better now. I'm good. Because okay, we'll continue. So she have to stop getting my blood. I have to go redo it again. Oh, yes, I was. I was super stressed. So that cortisol level accelerated the amount of
John Malanca 45:57
it's funny yesterday, I did my blood tests. And they did 33 panels. And I laugh because the very last one here. Yeah. This is cortisol. After reading all these, so I was in there. And even the lady that took my blood yesterday. She's like, Oh, my God. I said, I know. So she printed out 33 labels. And I said, well, at least you'll never forget, because she went right down to John Malanca, John Malanca. And she wanted to make sure that I could see all that and I go, Alicia, what you won't forget me how she was. I won't forget you. But anyway, LAN, I appreciate you coming on. Again. You've been a fan of United PageGroup, the show and what we've done over the years, even with the sacred plant. We did things in Dr. Franco's office. And so I love what you where you started and where you're going. I mean, congratulations, I, you know, I'm a big fan of people having success and whatever they're doing, but to do this, and like I said, everything you're doing, I've piecemealed out and now knowing that you can do that. And so again, for our audience, thank you, Len for that you. The code 20% off code is up g 20. Len is always available. I should say Erie is reachable, I should say. You know, they do have great customer service people answer emails, phone calls, et cetera over there. And so you can find Leonard and that can help but the website is endo d n a.com e n do dna.com. Any any parting words for our audience?
Len May 47:33
This is great, man. I just missed seeing your face. It's great to catch up like this and to be catchy. I mean, I'm, I'm grateful to have people in this industry that are here and doing things for the right reasons. We're in a really weird time right now. And you know, as a company was raising our series B, you get to see a whole new breed of cannabis people. And it's it's interesting, the people that have been in it for so long, that have alignment of mission and the new people that are coming into the industry. So I appreciate you. I have a lot of love for you. And I thank you so much for having me on
John Malanca 48:09
right back at you too. So everyone led me This is John Malanca. With United patient group be informed and be well and we'll see you soon. Have a great day everyone. Bye bye.